12. Renee Russo
Throughout the 90s, she was the rare leading lady who could go toe to toe with the era's biggest men, starring opposite Mel Gibson, Clint Eastwood, and John Travolta in hits like Lethal Weapon 3, In the Line of Fire, and Get Shorty. After the 2005 comedy Yours, Mine & Ours, she stepped away for years, citing burnout and depression after a lifetime of nonstop work, and she's since been candid about living with bipolar disorder. The break proved temporary, with a return as Thor's mother Frigga in the Marvel films and a celebrated, award-winning turn in 2014's Nightcrawler, directed by her husband Dan Gilroy. | © Columbia Pictures