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The Most Influential Female Actresses Of The 2000s

1-25

Nazarii Verbitskiy Nazarii Verbitskiy
Entertainment - June 30th 2025, 19:00 GMT+2
Kirsten Dunst

25. Kirsten Dunst

Kirsten Dunst became one of the defining faces in Hollywood with her captivating performances and girl-next-door charm. Her role as Mary Jane Watson in the Spider-Man trilogy brought her global recognition, while her nuanced portrayal in Marie Antoinette highlighted her dramatic depth. | © Marvel Studios

Diane Keaton

24. Diane Keaton

Diane Keaton continued to charm audiences in the 2000s with her iconic wit and timeless appeal. Her Golden Globe-winning performance in Something's Gotta Give showcased her comedic brilliance and emotional range. | © eOne

Amy Adams

23. Amy Adams

Amy Adams captivated the 2000s with her luminous charm and undeniable talent. Her Oscar-nominated performance in Junebug showcased her profound emotional depth, while hits like Enchanted and Doubt displayed her remarkable versatility. | © Universal Pictures

Julianne Moore

22. Julianne Moore

Julianne Moore captivated audiences throughout the 2000s with her emotionally resonant and nuanced performances. Her Oscar-nominated roles in Far from Heaven and The Hours showcased her extraordinary ability to portray complex, multi-faceted characters with profound depth. | © The Weinstein Company

Christina Ricci

21. Christina Ricci

Christina Ricci solidified her status as a captivating actress in the 2000s with her fearless choice of complex and unconventional roles in films like Monster and Black Snake Moan. Her willingness to delve into dark and challenging characters made her a standout, solidifying her reputation as one of the most influential female actresses. | © Miramax Films

Jennifer Aniston

20. Jennifer Aniston

Jennifer Aniston became a cultural icon and social media star in the 2000s, transitioning seamlessly from her beloved role in Friends to a successful film career. Starring in hits like The Break-Up and Marley & Me, she showcased her comedic timing and relatable charm. | © Warner Bros. Pictures

Cameron Diaz

19. Cameron Diaz

From her comedic triumphs in Charlie's Angels and Shrek to her poignant performance in Vanilla Sky, Cameron Diaz effortlessly navigated diverse roles, showcasing her remarkable versatility. Her box-office success and enduring charm made her one of the most influential stars of the decade. | © 20th Century Fox

Natalie Portman

18. Natalie Portman

Natalie Portman showcased her incredible range, from her hauntingly raw performance in Closer, which earned her an Oscar nomination, to her iconic role as Padmé Amidala in the Star Wars prequels. Her intelligence and dedication to her craft set her apart, making her one of the most respected actresses. | © Warner Bros. Pictures

Diane Lane

17. Diane Lane

Known for her nuanced portrayals in films like Under the Tuscan Sun and Nights in Rodanthe, Diana Lane brought elegance and emotions to Hollywood in the 2000s. She also earned an Oscar nomination for her captivating performance in Unfaithful, consistently delivering compelling performances. | © Warner Bros. Pictures

Jennifer Lopez

16. Jennifer Lopez

Jennifer Lopez reigned supreme in the 2000s, captivating audiences as both a mesmerizing screen siren and a global icon. From her breakout role in The Wedding Planner to her commanding performance in Selena, she proved her acting chops alongside her music career. | © Warner Bros. Pictures

Reese Witherspoon

15. Reese Witherspoon

Reese Witherspoon dominated the 2000s with her Oscar-winning performance as June Carter Cash in Walk the Line, which showcased her dramatic range and emotional depth. She also inspired countless young women to pursue their dreams, making her one of the most inspiring actresses of the decade. | © Lionsgate

Penélope Cruz

14. Penélope Cruz

Penélope Cruz achieved a historic milestone as the first Spanish actress to win an Academy Award for her passionate performance in Vicky Cristina Barcelona. Her effortless elegance and undeniable talent transcended borders, solidifying her status as a groundbreaking icon of the decade. | © Samuel Goldwyn Films

Charlize Theron

13. Charlize Theron

Charlize Theron exploded onto the scene in the 2000s, shattering expectations with a career defined by audacious choices and unparalleled talent. Her fearless transformation into the serial killer Aileen Wuornos in Monster was a cinematic revelation, earning her a well-deserved Academy Award. | © Warner Bros. Pictures

Sandra Bullock

12. Sandra Bullock

Sandra Bullock cemented her status as one of the most influential figures in Hollywood. Her Oscar-winning performance in The Blind Side showcased her ability to deliver heart-wrenching emotion, while box office hits like Miss Congeniality and The Proposal proved her impeccable comedic timing. | © Paramount Pictures

Hilary Swank

11. Hilary Swank

Hilary Swank left an indelible mark on the 2000s with her transformative performances in Boys Don't Cry and Million Dollar Baby, both of which earned her Academy Awards. Her intense dedication and ability to embody complex characters with raw emotion solidified her reputation as a respected talent. | © Warner Bros. Pictures

Julia Roberts

10. Julia Roberts

Julia Roberts won an Oscar in 2001 for her empowering performance in Erin Brockovich. She also Julia Roberts has her versatility by taking on a wide range of roles like Ocean’s Eleven and Closer, showcasing her range from drama to romance. | © Universal Pictures

Halle Berry

9. Halle Berry

Halle Berry made history in the 2000s, becoming the first black woman to win the Best Actress Oscar for her stunning performance in Monster’s Ball. She proved her versatility with roles ranging from the action-packed Die Another Day to the superhero drama X-Men, which made her one of the most influential female figures in Hollywood. | © Marvel Studios

Lost in Translation

8. Scarlett Johansson

Scarlett Johansson was established as a rising star in the 2000s, all thanks to her breakout performances in Lost in Translation and Girl with a Pearl Earring. As she seamlessly transitioned to Marvel Universe hits like Iron Man 2, Johansson became one of the most versatile and influential actresses of her generation. | © Focus Features

Nicole Kidman

7. Nicole Kidman

Nicole Kidman won an Oscar for her amazing performance as Virginia Woolf and showed off her incredible range in films like Moulin Rouge! and The Others. Kidman always took on challenging roles and had this amazing presence on screen, making her one of the most impactful actresses of the decade. | © 20th Century Fox

Renée Zellweger

6. Renée Zellweger

Renée Zellweger was a major star in the 2000s, captivating audiences with her charm and impressive range. She won an Oscar for her moving performance in Cold Mountain and became a beloved icon as Bridget Jones. From musicals to dramas, Zellweger consistently delivered captivating performances, making her one of the defining stars of the decade. | © 20th Century Fox

Cate Blanchett

5. Cate Blanchett

Cate Blanchett elevated the standards of acting with her Oscar-winning performance in The Aviator and her captivating work in Elizabeth: The Golden Age and The Curious Case of Benjamin Button. Her regal presence and fearless choices set a new standard for actors in the industry. | © Miramax Films

Keira Knightley

4. Keira Knightley

Keira Knightley was one of the defining actresses of the 2000s, captivating audiences with her elegant and emotionally nuanced performances in movies like Pride & Prejudice and Pirates of the Caribbean. These roles garnered critical acclaim and Oscar nominations, solidifying her status as a leading figure in the genre. | © Disney

Angelina Jolie

3. Angelina Jolie

Angelina Jolie, widely considered one of the most beautiful actresses of all time, has left an undeniable mark on Hollywood in the 2000s. Her career, marked by dramatic depth, is evident in roles ranging from the Oscar-nominated Changeling to action-packed films like Lara Croft: Tomb Raider and Wanted. | © Disney

Kate Winslet

2. Kate Winslet

Kate Winslet is a critically acclaimed actress known for her powerful and emotionally raw performances. With an Academy Award, two Golden Globes, and four BAFTAs, she has consistently delivered captivating portrayals in films like Titanic, Revolutionary Road, and The Reader. | © New Line Cinema

Meryl Streep

1. Meryl Streep

Meryl Streep is a legendary actress renowned for her unparalleled versatility and emotional depth, also renowned as an undisputed Queen of Cinema. Winning multiple Oscars and Golden Globes during this era, she delivered iconic performances in films like The Devil Wears Prada and Doubt.

Do you agree with our ranking? Let us know in the comments! | © First Independent Pictures

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